Strict Standards: Non-static method Loader::_is_included() should not be called statically in /www/htdocs/w00d1f37/html/subdomains/blog/includes/Loader.class.php on line 319

Strict Standards: Non-static method Loader::requireOnce() should not be called statically in /www/htdocs/w00d1f37/html/subdomains/blog/includes/pnAPI.php on line 1193

Strict Standards: Non-static method Loader::_is_included() should not be called statically in /www/htdocs/w00d1f37/html/subdomains/blog/includes/Loader.class.php on line 316

Strict Standards: Non-static method Loader::_is_included() should not be called statically in /www/htdocs/w00d1f37/html/subdomains/blog/includes/Loader.class.php on line 319

Strict Standards: Non-static method Loader::requireOnce() should not be called statically in /www/htdocs/w00d1f37/html/subdomains/blog/includes/pnAPI.php on line 293

Strict Standards: Non-static method Loader::_is_included() should not be called statically in /www/htdocs/w00d1f37/html/subdomains/blog/includes/Loader.class.php on line 316

Strict Standards: Non-static method Loader::_is_included() should not be called statically in /www/htdocs/w00d1f37/html/subdomains/blog/includes/Loader.class.php on line 319

Strict Standards: Non-static method Loader::loadClass() should not be called statically in /www/htdocs/w00d1f37/html/subdomains/blog/includes/pnAPI.php on line 294

Strict Standards: Non-static method Loader::loadFile() should not be called statically in /www/htdocs/w00d1f37/html/subdomains/blog/includes/Loader.class.php on line 157

Strict Standards: Non-static method DataUtil::formatForOS() should not be called statically in /www/htdocs/w00d1f37/html/subdomains/blog/includes/Loader.class.php on line 45

Strict Standards: Non-static method Loader::_is_included() should not be called statically in /www/htdocs/w00d1f37/html/subdomains/blog/includes/Loader.class.php on line 46

Strict Standards: Non-static method Loader::loadFile() should not be called statically in /www/htdocs/w00d1f37/html/subdomains/blog/includes/Loader.class.php on line 159

Strict Standards: Non-static method DataUtil::formatForOS() should not be called statically in /www/htdocs/w00d1f37/html/subdomains/blog/includes/Loader.class.php on line 45

Strict Standards: Non-static method Loader::_is_included() should not be called statically in /www/htdocs/w00d1f37/html/subdomains/blog/includes/Loader.class.php on line 46

Strict Standards: Non-static method Loader::includeOnce() should not be called statically in /www/htdocs/w00d1f37/html/subdomains/blog/includes/Loader.class.php on line 51

Strict Standards: Non-static method Loader::_is_included() should not be called statically in /www/htdocs/w00d1f37/html/subdomains/blog/includes/Loader.class.php on line 288

Strict Standards: Non-static method Loader::_is_included() should not be called statically in /www/htdocs/w00d1f37/html/subdomains/blog/includes/Loader.class.php on line 290

Strict Standards: Non-static method Loader::requireOnce() should not be called statically in /www/htdocs/w00d1f37/html/subdomains/blog/includes/pnAPI.php on line 295

Strict Standards: Non-static method Loader::_is_included() should not be called statically in /www/htdocs/w00d1f37/html/subdomains/blog/includes/Loader.class.php on line 316

Strict Standards: Non-static method Loader::_is_included() should not be called statically in /www/htdocs/w00d1f37/html/subdomains/blog/includes/Loader.class.php on line 319

Strict Standards: Non-static method Loader::loadClass() should not be called statically in /www/htdocs/w00d1f37/html/subdomains/blog/includes/pnAPI.php on line 296

Strict Standards: Non-static method Loader::loadFile() should not be called statically in /www/htdocs/w00d1f37/html/subdomains/blog/includes/Loader.class.php on line 157

Strict Standards: Non-static method DataUtil::formatForOS() should not be called statically in /www/htdocs/w00d1f37/html/subdomains/blog/includes/Loader.class.php on line 45

Strict Standards: Non-static method Loader::_is_included() should not be called statically in /www/htdocs/w00d1f37/html/subdomains/blog/includes/Loader.class.php on line 46

Strict Standards: Non-static method Loader::loadFile() should not be called statically in /www/htdocs/w00d1f37/html/subdomains/blog/includes/Loader.class.php on line 159

Strict Standards: Non-static method DataUtil::formatForOS() should not be called statically in /www/htdocs/w00d1f37/html/subdomains/blog/includes/Loader.class.php on line 45

Strict Standards: Non-static method Loader::_is_included() should not be called statically in /www/htdocs/w00d1f37/html/subdomains/blog/includes/Loader.class.php on line 46

Strict Standards: Non-static method Loader::includeOnce() should not be called statically in /www/htdocs/w00d1f37/html/subdomains/blog/includes/Loader.class.php on line 51

Strict Standards: Non-static method Loader::_is_included() should not be called statically in /www/htdocs/w00d1f37/html/subdomains/blog/includes/Loader.class.php on line 288

Strict Standards: Non-static method Loader::_is_included() should not be called statically in /www/htdocs/w00d1f37/html/subdomains/blog/includes/Loader.class.php on line 290

Strict Standards: Non-static method Loader::loadClass() should not be called statically in /www/htdocs/w00d1f37/html/subdomains/blog/includes/pnAPI.php on line 297

Strict Standards: Non-static method Loader::loadFile() should not be called statically in /www/htdocs/w00d1f37/html/subdomains/blog/includes/Loader.class.php on line 157

Strict Standards: Non-static method DataUtil::formatForOS() should not be called statically in /www/htdocs/w00d1f37/html/subdomains/blog/includes/Loader.class.php on line 45

Strict Standards: Non-static method Loader::_is_included() should not be called statically in /www/htdocs/w00d1f37/html/subdomains/blog/includes/Loader.class.php on line 46

Strict Standards: Non-static method Loader::loadFile() should not be called statically in /www/htdocs/w00d1f37/html/subdomains/blog/includes/Loader.class.php on line 159

Strict Standards: Non-static method DataUtil::formatForOS() should not be called statically in /www/htdocs/w00d1f37/html/subdomains/blog/includes/Loader.class.php on line 45

Strict Standards: Non-static method Loader::_is_included() should not be called statically in /www/htdocs/w00d1f37/html/subdomains/blog/includes/Loader.class.php on line 46

Strict Standards: Non-static method Loader::includeOnce() should not be called statically in /www/htdocs/w00d1f37/html/subdomains/blog/includes/Loader.class.php on line 51

Strict Standards: Non-static method Loader::_is_included() should not be called statically in /www/htdocs/w00d1f37/html/subdomains/blog/includes/Loader.class.php on line 288

Strict Standards: Non-static method Loader::_is_included() should not be called statically in /www/htdocs/w00d1f37/html/subdomains/blog/includes/Loader.class.php on line 290

Strict Standards: Non-static method Loader::loadClass() should not be called statically in /www/htdocs/w00d1f37/html/subdomains/blog/includes/pnAPI.php on line 298

Strict Standards: Non-static method Loader::loadFile() should not be called statically in /www/htdocs/w00d1f37/html/subdomains/blog/includes/Loader.class.php on line 157

Strict Standards: Non-static method DataUtil::formatForOS() should not be called statically in /www/htdocs/w00d1f37/html/subdomains/blog/includes/Loader.class.php on line 45

Strict Standards: Non-static method Loader::_is_included() should not be called statically in /www/htdocs/w00d1f37/html/subdomains/blog/includes/Loader.class.php on line 46

Strict Standards: Non-static method Loader::loadFile() should not be called statically in /www/htdocs/w00d1f37/html/subdomains/blog/includes/Loader.class.php on line 159

Strict Standards: Non-static method DataUtil::formatForOS() should not be called statically in /www/htdocs/w00d1f37/html/subdomains/blog/includes/Loader.class.php on line 45

Strict Standards: Non-static method Loader::_is_included() should not be called statically in /www/htdocs/w00d1f37/html/subdomains/blog/includes/Loader.class.php on line 46

Strict Standards: Non-static method Loader::includeOnce() should not be called statically in /www/htdocs/w00d1f37/html/subdomains/blog/includes/Loader.class.php on line 51

Strict Standards: Non-static method Loader::_is_included() should not be called statically in /www/htdocs/w00d1f37/html/subdomains/blog/includes/Loader.class.php on line 288

Strict Standards: Non-static method Loader::_is_included() should not be called statically in /www/htdocs/w00d1f37/html/subdomains/blog/includes/Loader.class.php on line 290

Strict Standards: Non-static method Loader::loadClass() should not be called statically in /www/htdocs/w00d1f37/html/subdomains/blog/includes/pnAPI.php on line 299

Strict Standards: Non-static method Loader::loadFile() should not be called statically in /www/htdocs/w00d1f37/html/subdomains/blog/includes/Loader.class.php on line 157

Strict Standards: Non-static method DataUtil::formatForOS() should not be called statically in /www/htdocs/w00d1f37/html/subdomains/blog/includes/Loader.class.php on line 45

Strict Standards: Non-static method Loader::_is_included() should not be called statically in /www/htdocs/w00d1f37/html/subdomains/blog/includes/Loader.class.php on line 46

Strict Standards: Non-static method Loader::loadFile() should not be called statically in /www/htdocs/w00d1f37/html/subdomains/blog/includes/Loader.class.php on line 159

Strict Standards: Non-static method DataUtil::formatForOS() should not be called statically in /www/htdocs/w00d1f37/html/subdomains/blog/includes/Loader.class.php on line 45

Strict Standards: Non-static method Loader::_is_included() should not be called statically in /www/htdocs/w00d1f37/html/subdomains/blog/includes/Loader.class.php on line 46

Strict Standards: Non-static method Loader::includeOnce() should not be called statically in /www/htdocs/w00d1f37/html/subdomains/blog/includes/Loader.class.php on line 51

Strict Standards: Non-static method Loader::_is_included() should not be called statically in /www/htdocs/w00d1f37/html/subdomains/blog/includes/Loader.class.php on line 288

Strict Standards: Non-static method Loader::_is_included() should not be called statically in /www/htdocs/w00d1f37/html/subdomains/blog/includes/Loader.class.php on line 290

Strict Standards: Non-static method Loader::loadClass() should not be called statically in /www/htdocs/w00d1f37/html/subdomains/blog/includes/pnAPI.php on line 300

Strict Standards: Non-static method Loader::loadFile() should not be called statically in /www/htdocs/w00d1f37/html/subdomains/blog/includes/Loader.class.php on line 157

Strict Standards: Non-static method DataUtil::formatForOS() should not be called statically in /www/htdocs/w00d1f37/html/subdomains/blog/includes/Loader.class.php on line 45

Strict Standards: Non-static method Loader::_is_included() should not be called statically in /www/htdocs/w00d1f37/html/subdomains/blog/includes/Loader.class.php on line 46

Strict Standards: Non-static method Loader::loadFile() should not be called statically in /www/htdocs/w00d1f37/html/subdomains/blog/includes/Loader.class.php on line 159

Strict Standards: Non-static method DataUtil::formatForOS() should not be called statically in /www/htdocs/w00d1f37/html/subdomains/blog/includes/Loader.class.php on line 45

Strict Standards: Non-static method Loader::_is_included() should not be called statically in /www/htdocs/w00d1f37/html/subdomains/blog/includes/Loader.class.php on line 46

Strict Standards: Non-static method Loader::includeOnce() should not be called statically in /www/htdocs/w00d1f37/html/subdomains/blog/includes/Loader.class.php on line 51

Strict Standards: Non-static method Loader::_is_included() should not be called statically in /www/htdocs/w00d1f37/html/subdomains/blog/includes/Loader.class.php on line 288

Strict Standards: Non-static method Loader::_is_included() should not be called statically in /www/htdocs/w00d1f37/html/subdomains/blog/includes/Loader.class.php on line 290

Strict Standards: Non-static method Loader::loadClass() should not be called statically in /www/htdocs/w00d1f37/html/subdomains/blog/includes/pnAPI.php on line 301

Strict Standards: Non-static method Loader::loadFile() should not be called statically in /www/htdocs/w00d1f37/html/subdomains/blog/includes/Loader.class.php on line 157

Strict Standards: Non-static method DataUtil::formatForOS() should not be called statically in /www/htdocs/w00d1f37/html/subdomains/blog/includes/Loader.class.php on line 45

Strict Standards: Non-static method Loader::_is_included() should not be called statically in /www/htdocs/w00d1f37/html/subdomains/blog/includes/Loader.class.php on line 46

Strict Standards: Non-static method Loader::loadFile() should not be called statically in /www/htdocs/w00d1f37/html/subdomains/blog/includes/Loader.class.php on line 159

Strict Standards: Non-static method DataUtil::formatForOS() should not be called statically in /www/htdocs/w00d1f37/html/subdomains/blog/includes/Loader.class.php on line 45

Strict Standards: Non-static method Loader::_is_included() should not be called statically in /www/htdocs/w00d1f37/html/subdomains/blog/includes/Loader.class.php on line 46

Strict Standards: Non-static method Loader::includeOnce() should not be called statically in /www/htdocs/w00d1f37/html/subdomains/blog/includes/Loader.class.php on line 51

Strict Standards: Non-static method Loader::_is_included() should not be called statically in /www/htdocs/w00d1f37/html/subdomains/blog/includes/Loader.class.php on line 288

Strict Standards: Non-static method Loader::_is_included() should not be called statically in /www/htdocs/w00d1f37/html/subdomains/blog/includes/Loader.class.php on line 290

Strict Standards: Non-static method Loader::loadClass() should not be called statically in /www/htdocs/w00d1f37/html/subdomains/blog/includes/pnAPI.php on line 302

Strict Standards: Non-static method Loader::loadFile() should not be called statically in /www/htdocs/w00d1f37/html/subdomains/blog/includes/Loader.class.php on line 157

Strict Standards: Non-static method DataUtil::formatForOS() should not be called statically in /www/htdocs/w00d1f37/html/subdomains/blog/includes/Loader.class.php on line 45

Strict Standards: Non-static method Loader::_is_included() should not be called statically in /www/htdocs/w00d1f37/html/subdomains/blog/includes/Loader.class.php on line 46

Strict Standards: Non-static method Loader::loadFile() should not be called statically in /www/htdocs/w00d1f37/html/subdomains/blog/includes/Loader.class.php on line 159

Strict Standards: Non-static method DataUtil::formatForOS() should not be called statically in /www/htdocs/w00d1f37/html/subdomains/blog/includes/Loader.class.php on line 45

Strict Standards: Non-static method Loader::_is_included() should not be called statically in /www/htdocs/w00d1f37/html/subdomains/blog/includes/Loader.class.php on line 46

Strict Standards: Non-static method Loader::includeOnce() should not be called statically in /www/htdocs/w00d1f37/html/subdomains/blog/includes/Loader.class.php on line 51

Strict Standards: Non-static method Loader::_is_included() should not be called statically in /www/htdocs/w00d1f37/html/subdomains/blog/includes/Loader.class.php on line 288

Strict Standards: Non-static method Loader::_is_included() should not be called statically in /www/htdocs/w00d1f37/html/subdomains/blog/includes/Loader.class.php on line 290

Strict Standards: Declaration of PNObjectArray::setData() should be compatible with PNObject::setData($data, $cache = false) in /www/htdocs/w00d1f37/html/subdomains/blog/includes/PNObjectArray.class.php on line 507

Strict Standards: Declaration of PNObjectArray::get() should be compatible with & PNObject::get($key = 0, $field = 'id', $force = false) in /www/htdocs/w00d1f37/html/subdomains/blog/includes/PNObjectArray.class.php on line 507

Strict Standards: Declaration of PNObjectArray::getWhere() should be compatible with & PNObject::getWhere($where) in /www/htdocs/w00d1f37/html/subdomains/blog/includes/PNObjectArray.class.php on line 507

Strict Standards: Declaration of PNObjectArray::select() should be compatible with & PNObject::select($key, $field = 'id', $where = '') in /www/htdocs/w00d1f37/html/subdomains/blog/includes/PNObjectArray.class.php on line 507

Strict Standards: Declaration of PNObjectArray::getDataField() should be compatible with PNObject::getDataField($key, $default = NULL) in /www/htdocs/w00d1f37/html/subdomains/blog/includes/PNObjectArray.class.php on line 507

Strict Standards: Non-static method Loader::loadClass() should not be called statically in /www/htdocs/w00d1f37/html/subdomains/blog/includes/pnAPI.php on line 303

Strict Standards: Non-static method Loader::loadFile() should not be called statically in /www/htdocs/w00d1f37/html/subdomains/blog/includes/Loader.class.php on line 157

Strict Standards: Non-static method DataUtil::formatForOS() should not be called statically in /www/htdocs/w00d1f37/html/subdomains/blog/includes/Loader.class.php on line 45

Strict Standards: Non-static method Loader::_is_included() should not be called statically in /www/htdocs/w00d1f37/html/subdomains/blog/includes/Loader.class.php on line 46

Strict Standards: Non-static method Loader::loadFile() should not be called statically in /www/htdocs/w00d1f37/html/subdomains/blog/includes/Loader.class.php on line 159

Strict Standards: Non-static method DataUtil::formatForOS() should not be called statically in /www/htdocs/w00d1f37/html/subdomains/blog/includes/Loader.class.php on line 45

Strict Standards: Non-static method Loader::_is_included() should not be called statically in /www/htdocs/w00d1f37/html/subdomains/blog/includes/Loader.class.php on line 46

Strict Standards: Non-static method Loader::includeOnce() should not be called statically in /www/htdocs/w00d1f37/html/subdomains/blog/includes/Loader.class.php on line 51

Strict Standards: Non-static method Loader::_is_included() should not be called statically in /www/htdocs/w00d1f37/html/subdomains/blog/includes/Loader.class.php on line 288

Strict Standards: Non-static method Loader::_is_included() should not be called statically in /www/htdocs/w00d1f37/html/subdomains/blog/includes/Loader.class.php on line 290

Strict Standards: Non-static method Loader::loadClass() should not be called statically in /www/htdocs/w00d1f37/html/subdomains/blog/includes/pnAPI.php on line 304

Strict Standards: Non-static method Loader::loadFile() should not be called statically in /www/htdocs/w00d1f37/html/subdomains/blog/includes/Loader.class.php on line 157

Strict Standards: Non-static method DataUtil::formatForOS() should not be called statically in /www/htdocs/w00d1f37/html/subdomains/blog/includes/Loader.class.php on line 45

Strict Standards: Non-static method Loader::_is_included() should not be called statically in /www/htdocs/w00d1f37/html/subdomains/blog/includes/Loader.class.php on line 46

Strict Standards: Non-static method Loader::loadFile() should not be called statically in /www/htdocs/w00d1f37/html/subdomains/blog/includes/Loader.class.php on line 159

Strict Standards: Non-static method DataUtil::formatForOS() should not be called statically in /www/htdocs/w00d1f37/html/subdomains/blog/includes/Loader.class.php on line 45

Strict Standards: Non-static method Loader::_is_included() should not be called statically in /www/htdocs/w00d1f37/html/subdomains/blog/includes/Loader.class.php on line 46

Strict Standards: Non-static method Loader::includeOnce() should not be called statically in /www/htdocs/w00d1f37/html/subdomains/blog/includes/Loader.class.php on line 51

Strict Standards: Non-static method Loader::_is_included() should not be called statically in /www/htdocs/w00d1f37/html/subdomains/blog/includes/Loader.class.php on line 288

Strict Standards: Non-static method Loader::_is_included() should not be called statically in /www/htdocs/w00d1f37/html/subdomains/blog/includes/Loader.class.php on line 290

Strict Standards: Non-static method Loader::loadClass() should not be called statically in /www/htdocs/w00d1f37/html/subdomains/blog/includes/pnAPI.php on line 305

Strict Standards: Non-static method Loader::loadFile() should not be called statically in /www/htdocs/w00d1f37/html/subdomains/blog/includes/Loader.class.php on line 157

Strict Standards: Non-static method DataUtil::formatForOS() should not be called statically in /www/htdocs/w00d1f37/html/subdomains/blog/includes/Loader.class.php on line 45

Strict Standards: Non-static method Loader::_is_included() should not be called statically in /www/htdocs/w00d1f37/html/subdomains/blog/includes/Loader.class.php on line 46

Strict Standards: Non-static method Loader::loadFile() should not be called statically in /www/htdocs/w00d1f37/html/subdomains/blog/includes/Loader.class.php on line 159

Strict Standards: Non-static method DataUtil::formatForOS() should not be called statically in /www/htdocs/w00d1f37/html/subdomains/blog/includes/Loader.class.php on line 45

Strict Standards: Non-static method Loader::_is_included() should not be called statically in /www/htdocs/w00d1f37/html/subdomains/blog/includes/Loader.class.php on line 46

Strict Standards: Non-static method Loader::includeOnce() should not be called statically in /www/htdocs/w00d1f37/html/subdomains/blog/includes/Loader.class.php on line 51

Strict Standards: Non-static method Loader::_is_included() should not be called statically in /www/htdocs/w00d1f37/html/subdomains/blog/includes/Loader.class.php on line 288

Strict Standards: Non-static method Loader::_is_included() should not be called statically in /www/htdocs/w00d1f37/html/subdomains/blog/includes/Loader.class.php on line 290

Strict Standards: Non-static method Loader::loadClass() should not be called statically in /www/htdocs/w00d1f37/html/subdomains/blog/includes/pnAPI.php on line 306

Strict Standards: Non-static method Loader::loadFile() should not be called statically in /www/htdocs/w00d1f37/html/subdomains/blog/includes/Loader.class.php on line 157

Strict Standards: Non-static method DataUtil::formatForOS() should not be called statically in /www/htdocs/w00d1f37/html/subdomains/blog/includes/Loader.class.php on line 45

Strict Standards: Non-static method Loader::_is_included() should not be called statically in /www/htdocs/w00d1f37/html/subdomains/blog/includes/Loader.class.php on line 46

Strict Standards: Non-static method Loader::loadFile() should not be called statically in /www/htdocs/w00d1f37/html/subdomains/blog/includes/Loader.class.php on line 159

Strict Standards: Non-static method DataUtil::formatForOS() should not be called statically in /www/htdocs/w00d1f37/html/subdomains/blog/includes/Loader.class.php on line 45

Strict Standards: Non-static method Loader::_is_included() should not be called statically in /www/htdocs/w00d1f37/html/subdomains/blog/includes/Loader.class.php on line 46

Strict Standards: Non-static method Loader::includeOnce() should not be called statically in /www/htdocs/w00d1f37/html/subdomains/blog/includes/Loader.class.php on line 51

Strict Standards: Non-static method Loader::_is_included() should not be called statically in /www/htdocs/w00d1f37/html/subdomains/blog/includes/Loader.class.php on line 288

Strict Standards: Non-static method Loader::_is_included() should not be called statically in /www/htdocs/w00d1f37/html/subdomains/blog/includes/Loader.class.php on line 290

Strict Standards: Non-static method DBConnectionStack::init() should not be called statically in /www/htdocs/w00d1f37/html/subdomains/blog/includes/pnAPI.php on line 474

Deprecated: mysql_connect(): The mysql extension is deprecated and will be removed in the future: use mysqli or PDO instead in /www/htdocs/w00d1f37/html/subdomains/blog/includes/classes/adodb/drivers/adodb-mysql.inc.php on line 367

Strict Standards: Non-static method Loader::loadOneFile() should not be called statically in /www/htdocs/w00d1f37/html/subdomains/blog/includes/pnMod.php on line 506

Strict Standards: Non-static method Loader::loadFiles() should not be called statically in /www/htdocs/w00d1f37/html/subdomains/blog/includes/Loader.class.php on line 93

Strict Standards: Non-static method Loader::loadFile() should not be called statically in /www/htdocs/w00d1f37/html/subdomains/blog/includes/Loader.class.php on line 119

Strict Standards: Non-static method DataUtil::formatForOS() should not be called statically in /www/htdocs/w00d1f37/html/subdomains/blog/includes/Loader.class.php on line 45

Strict Standards: Non-static method Loader::_is_included() should not be called statically in /www/htdocs/w00d1f37/html/subdomains/blog/includes/Loader.class.php on line 46

Strict Standards: Non-static method Loader::loadFile() should not be called statically in /www/htdocs/w00d1f37/html/subdomains/blog/includes/Loader.class.php on line 119

Strict Standards: Non-static method DataUtil::formatForOS() should not be called statically in /www/htdocs/w00d1f37/html/subdomains/blog/includes/Loader.class.php on line 45

Strict Standards: Non-static method Loader::_is_included() should not be called statically in /www/htdocs/w00d1f37/html/subdomains/blog/includes/Loader.class.php on line 46

Strict Standards: Non-static method Loader::includeOnce() should not be called statically in /www/htdocs/w00d1f37/html/subdomains/blog/includes/Loader.class.php on line 51

Strict Standards: Non-static method Loader::_is_included() should not be called statically in /www/htdocs/w00d1f37/html/subdomains/blog/includes/Loader.class.php on line 288

Strict Standards: Non-static method Loader::_is_included() should not be called statically in /www/htdocs/w00d1f37/html/subdomains/blog/includes/Loader.class.php on line 290

Strict Standards: Non-static method Loader::loadOneFile() should not be called statically in /www/htdocs/w00d1f37/html/subdomains/blog/includes/pnMod.php on line 506

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Depressionen beschleunigen dramatisch die Zellalterung | Nachrichten, die uns bewegen
   

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Soziales Dorf: Projektstand

Depressionen beschleunigen dramatisch die Zellalterung

Eingereicht von Detlef am 15. Nov 2013 - 09:00 Uhr             Seitenaufrufe: 3664

Bild 0 für Depressionen beschleunigen dramatisch die Zellalterung

Labortests von Forschern in den Niederlanden und USA zeigen deutliche Unterschiede bei Chromosom-Schutzkappen

Amsterdam (pte). Depressionen können physisch älter machen, indem sie den Alterungsprozess unserer Zellen beschleunigen. Zu diesem Ergebnis kommt eine aktuelle Studie, die Forscher der VU University Medical Centre (VUmc) in Amsterdam gemeinsam mit US-Kollegen durchgeführt haben. 
Demnach konnte mittels Labortests nachgewiesen werden, dass die Zellen von jenen Menschen, die gegenwärtig schwer depressiv sind oder in der Vergangenheit an einer Depression litten, unter dem Mikroskop deutlich älter erscheinen. 


Die sichtbaren Unterschiede betreffen dabei vor allem die sogenannten Telomere - die Schutzkappen am Ende der Chromosomen - und lassen sich nicht durch andere Faktoren wie etwa starkes Rauchen oder übermäßigen Alkoholkonsum erklären, betonen die Studienautoren. 


Verschiedene Einflussfaktoren

"Der Alterungsprozess einer Zelle hängt von verschiedenen Faktoren ab", erklärt Roland Foisner, Professor für Biochemie an der Meduni Wien und Gruppenleiter an den Max F. Perutz Laboratories, gegenüber pressetext. Als Beispiel verweist der Zellbiologe unter anderem auf Umwelteinflüsse wie eine direkte Sonneneinstrahlung, die die Hautzellen schädigen können. "Aber auch innere Einflüsse spielen hierbei eine Rolle. So führt etwa das Einatmen von Sauerstoff, wenn er nicht komplett verarbeitet wird, zur Bildung von freien Radikalen, die sich negativ auf die Zellen auswirken können", erläutert der Wissenschaftler.

Die Bedeutung der Telomere für den Alterungsprozess sei bereits bekannt. "Dahinter versteckt sich eine Art Schutzmechanismus für den Organismus. Prinzipiell gilt: Je kürzer die Länge der Tolemere, desto älter ist der Körper und desto geringer ist die Lebenserwartung", fasst Foisner zusammen. Hier gelte es allerdings auch Unterschiede zwischen Mensch und Tier zu beachten. Bei Mäusen sind die Tolemere nämlich deutlich länger als beim Homo sapiens. "Die Tatsache, dass diese Unterschiede existieren, zeigt, dass es auch noch andere wichtige Faktoren geben muss, die den Altersprozess beeinflussen. Ob hier auch psychische Störungen wie Depressionen mitspielen, lässt sich auch durch die aktuelle US-Studie nicht endgültig klären", meint der Experte.


"Schlagkräftige Beweise"

Die Studienautoren selbst wollen mit ihrer Untersuchung freilich "schlagkräftige Beweise" für diesen Zusammenhang gefunden haben. "Unsere groß angelegte Studie zeigt, dass Depression mehrere Jahre des biologischen Alters mit sich bringt, insbesondere dann, wenn die Betroffenen sehr ernste chronische Symptome aufweisen", zitiert BBC News die VUmc-Forscherin Josine Verhoeven. Insgesamt 2.407 Menschen hat sie gemeinsam mit US-Kollegen unter die Lupe genommen. Mehr als ein Drittel davon war gerade depressiv, ein Drittel litt in der Vergangenheit unter einer schweren Depression und der Rest hatte nie ein derartiges Problem.

Für die Analyse mussten die freiwilligen Studienteilnehmer eine Blutprobe abgeben, die im Labor nach Anzeichen der Zellalterung überprüft wurde. Dabei stellte sich heraus, dass Menschen aus den ersten beiden Gruppen deutlich kürzere Telomere aufwiesen als die Mitglieder der nicht-depressiven Kontrollgruppe.
"Verkürzte Telomere sind eine Reaktion des Körpers auf den Stress, den eine Depression hervorruft", bringt Verhoeven ihre Untersuchungsergebnisse auf den Punkt. Unklar sei, ob sich dieser Prozess auch umkehren lässt, so die Forscherin abschließend.

Aussender: pressetext.redaktion 
Ansprechpartner: Markus Steiner
Tel.: +43-1-81140-317
E-Mail: steiner@pressetext.com
Website: www.pressetext.com

Quelle: pressetext



Anmerkungen:
Eine Depression bringt mehrere Jahre des biologischen Alters mit sich.
FOTO: Wolfgang Pfensig / pixelio.de


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